🎙️✨ Isotretinoin + Clascoterone: Acne’s New Power Couple?

When acne gets severe, isotretinoin usually enters the chat as the big gun.💥
But what happens when you pair it with topical clascoterone — the anti-androgen sidekick targeting the sebaceous gland from another angle?

In this episode, we break down new real-world data from a multi-centre retrospective study comparing oral isotretinoin monotherapy versus combination isotretinoin + topical clascoterone for severe acne vulgaris and what the implications are for clinic.

And yes — the combo arm brought some serious main-character energy.

Our expert guests unpack what this could mean in clinic:
✨ faster clearance
✨ improved tolerability
✨ hormonal acne considerations
✨ patient adherence realities
✨ the ever-important goal of preventing scars before they happen

Because in acne care, almost clear is nice… but clear-clear is the assignment. ✅

This conversation dives into the practical side: When should clascoterone be added? Which patients may benefit most? How do we keep regimens simple for younger patients already juggling isotretinoin, labs, moisturizers, sunscreen, and TikTok skincare detox?

Learning objectives:
✅ Review emerging data comparing isotretinoin monotherapy with isotretinoin plus topical clascoterone in severe acne vulgaris
✅ Discuss the potential clinical relevance of combination therapy for clearance, tolerability, and patient experience
✅ Explore practical approaches to integrating clascoterone into isotretinoin treatment plans
✅ Consider real-world limitations of retrospective data, including confounders, dosing variation, skincare use, and patient selection
✅ Reframe acne treatment goals beyond lesion counts to include scarring prevention, satisfaction, and long-term disease control

🎧 AAD 2026 coverage from the Mile High City. Special thanks Dr. Mohannad Abu-Hilal.

#SkinAndJointsPodcast #AAD2026 #Dermatology #Acne #AcneVulgaris #Isotretinoin #Clascoterone #Winlevi #DermTwitter #MedEd #DermatologyEducation #SevereAcne #AcneScarring #SkinHealth #ClinicalDermatology #Vodcast #Podcast #HealthcareEducation

ABOUT Dr. Renée A. Beach MD FRCPC DABD Dermatologist | Toronto, ON

Dr. Renée A. Beach is a dermatologist practicing in Toronto for more than 10 years. She earned her medical doctor (MD) degree from McMaster University, followed by Dermatology residency at the University of Ottawa (FRCPC).

As an adjunct assistant professor at the University of Toronto, she teaches trainees in the Undergraduate MD program as well as postgraduate dermatology residents and has collaborated with them on various peer-reviewed publications. She is a trusted, regularly sought-after authority across media outlets and is the on-air dermatologist for CTVs The Social and Your Morning. On social media, she is active on Instagram (@dermabeach).

At her private office, DermAtelier on Avenue, she sees patients for medical and cosmetic treatments with the goal of delivering dermatologic excellence to patients of all skin tones and types

About Dr. Irina Oroz, MD FRCPC DABD Dermatologist | Saskatoon, SK

Dr. Irina Oroz is a fellow of the Royal College of Physicians and Surgeons of Canada in Dermatology, a Diplomate of the American Board of Dermatology, and Assistant Clinical Professor of Dermatology at the University of Saskatchewan.

Currently she practices medical, surgical and cosmetic dermatology at Oroz Dermatology in Saskatoon. Her areas of interest lie in skin cancer, acne and psoriasis.

Dr. Oroz completed her medical degree at the University of Saskatchewan, prior to undertaking a five-year dermatology residency program at the University of Saskatchewan and University of Alberta. Her interest in the diagnosis and management of skin disease has been enhanced with elective training in USA, Australia and across Canada, with specialized training in Skin Cancer at the Royal Alexandra Hospital in Brisbane Australia, as well as medical education research in Edmonton.

Active in the medical community, Dr. Oroz is one of the founding members, as well as the current treasurer of the Saskatchewan Dermatology Association.

Supported by an IME Grant from SUN Pharma.

📻www.skinandjoints.ca

✉️info@skinandjoints.ca

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